Papers with clinical language models
Evaluating Pretraining Strategies for Clinical BERT Models (2022.lrec-1)
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| Challenge: | Existing generic language models in specialized domains may be sub-optimal due to domain differences. |
| Approach: | They propose various strategies for adapting a generic language model to the target domain and various forms of vocabulary modifications to fine-tune it. |
| Outcome: | The proposed strategies outperform a general-domain language model but little difference in performance between the models. |
Publicly Shareable Clinical Large Language Model Built on Synthetic Clinical Notes (2024.findings-acl)
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Sunjun Kweon, Junu Kim, Jiyoun Kim, Sujeong Im, Eunbyeol Cho, Seongsu Bae, Jungwoo Oh, Gyubok Lee, Jong Hak Moon, Seng Chan You, Seungjin Baek, Chang Hoon Han, Yoon Bin Jung, Yohan Jo, Edward Choi
| Challenge: | Clinical notes are an extensive repository of information specific to individual patients. |
| Approach: | They create synthetic large-scale clinical notes using publicly available case reports extracted from biomedical literature and train a clinical large language model, Asclepius. |
| Outcome: | The proposed model outperforms several other models and is supported by detailed evaluations conducted by GPT-4 and medical professionals. |
Attention Networks for Augmenting Clinical Text with Support Sets for Diagnosis Prediction (2022.coling-1)
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| Challenge: | Clinical language models may suffer from imbalanced vocabulary for describing diseases or symptoms. |
| Approach: | They propose to augment clinical text with potentially complementary diagnostic codes from prior admissions or as they emerge during differential diagnosis to improve the performance. |
| Outcome: | The proposed approach outperforms the previous state-of-the-art PubMedBERT by up 3% points. |
Building Trust in Clinical LLMs: Bias Analysis and Dataset Transparency (2025.emnlp-main)
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Svetlana Maslenkova, Clement Christophe, Marco AF Pimentel, Tathagata Raha, Muhammad Umar Salman, Ahmed Al Mahrooqi, Avani Gupta, Shadab Khan, Ronnie Rajan, Praveenkumar Kanithi
| Challenge: | Current dataset curation and bias assessment practices lack transparency . current approaches lack a thorough understanding of how data characteristics influence model behavior . |
| Approach: | They propose a comprehensive bias evaluation framework that integrates general benchmarks with a healthcare-specific methodology to probe for biases in a sensitive healthcare context. |
| Outcome: | The proposed approach to bias evaluation leverages established benchmarks and a healthcare-specific methodology. |